August 2018 Vol. 2 No. 5
The beginning of the 2018–2019 academic year marks the 121st start of classes at the UNC Eshelman School of Pharmacy. I want to extend the warmest of welcomes to our professional and graduate students with a special welcome to the members of the Class of 2022, which for the first time includes three students from China who are the first recipients of support from the China Scholarship Council. The CSC has an agreement with the School to provide support for up to 35 Pharm.D. students and up to 25 students admitted to the Ph.D. program from China over the next five years.
We are continuing our search for the next dean of the UNC Eshelman School of Pharmacy. The search committee forwarded three candidate names to Provost Bob Blouin for consideration. Two of the three candidates interviewed with the provost, Chancellor Carol Folt and two senior members of the chancellor’s cabinet. Subsequently, after a great deal of deliberation and consideration, the provost has decided to continue the search process.
Provost Blouin made it clear this decision was not made lightly, and we recognize that this will put additional demands on the search committee and School community. The University’s goal is to hire the right person who has all of the experiences and skills needed to ensure the School achieves its true potential in an increasingly complex and competitive landscape. This person must understand and appreciate the profession of pharmacy, be respected within the academy and be fearless in their aspirations for the School,.
I will continue to serve you in my role as interim dean.
Congratulations to Rick Wernoski for his promotion to senior vice provost for business operations for the University. He will play a key role in assisting Provost Blouin in reengineering the operations and infrastructure of the campus. This is a great opportunity for Rick, and I want all of us to celebrate his success and thank him for his service to the School for the past eight years. Rick joined the Office of the Provost on Sept. 4 but will continue to work with and support us after while we search for his successor. Rick’s departure will be a big loss to the School, the institute, and personally to me. However, I am pleased that we are losing Rick to the University, where he will work with the same energy to make the University better just as he did for the School.
On Aug. 14, the School held its first Transformative Diversity and Inclusion Retreat led by Assistant Dean Carla White and the Office of Leadership and Diversity. The turnout of faculty, students and staff was impressive, and I was extremely gratified to see everyone’s interest in finding opportunities to enhance diversity and inclusion within the School. A core part of our mission is a continued pursuit of a culture where all feel welcomed, valued and respected, and we will continue to strive toward this goal with your help.
Finally, I want to acknowledge the passing of one of the greats. Dr. Alan Forrest, one of our faculty members in the Division of Pharmacotherapy and Experimental Therapeutics, died Aug. 25. Although seriously ill, he fought a gallant fight as he believed that he had much to accomplish yet.
Alan contributed to the field of pharmacokinetic and pharmacodynamic modeling for well over 30 years as a highly productive and innovative researcher and an educator. He was world-renowned for his work on the use of quantitative approaches and mathematical modeling to optimize patient therapy, and he significantly affected drug development and pharmacotherapy through his contributions in evolving the field of pharmacometrics. He will be sorely missed by his colleagues in the School and around the world and by his students, who were his passion.
Ferguson Distinguished Professor
Alan Forrest, Pharm.D., 66, a clinical professor at the UNC Eshelman School of Pharmacy and expert in pharmacokinetic and pharmacodynamics modeling, died Saturday, Aug. 25, at UNC Hospitals.
“Alan contributed to the field of pharmacokinetic and pharmacodynamic modeling for well over 30 years as a highly productive and innovative researcher and an educator,” said Dhiren Thakker, Ph.D., interim dean of the School. “He was world renowned for his work on the use of quantitative approaches and mathematical modeling to optimize patient therapy, and he significantly impacted drug development and pharmacotherapy through his contributions in evolving the field of pharmacometrics.
“Alan will be sorely missed by his colleagues in the School and around the world and by students who were his passion.”
Amanda Corbett, Pharm.D., has been appointed assistant dean for the professional curriculum of the UNC Eshelman School of Pharmacy.
Corbett is a clinical associate professor in the Division of Pharmacotherapy and Experimental Therapeutics and serves as the associate director of global engagement at the School. She is also a clinical associate professor in the UNC School of Medicine and global pharmacology coordinator for the UNC Institute of Global Health and Infectious Diseases.
As assistant dean, Corbett will work with the faculty and students to implement educational innovation into the professional curriculum and integrate it with the School’s residential, experiential, global and rural curricula. She assumed her new role on Aug. 1.
The University of North Carolina at Chapel Hill ranks fifth in the world in pharmacy and pharmaceutical sciences, up one spot from last year, according to the 2018 Academic Ranking of World Universities released by the ShanghaiRanking Consultancy, in conjunction with the Center for World Class Universities at Shanghai Jiao Tong University on August 15.
The UNC Eshelman School of Pharmacy is the top-ranked pharmacy school in the United States, according to U.S. News & World Report.
The University ranked 6th in pharmacy and pharmaceutical sciences in 2017. Overall, UNC-Chapel Hill ranks 30th in the world and 22nd in the U.S. among global universities. This places UNC-Chapel Hill as 9th among U.S. public universities in the global ranking.
The UNC Eshelman School of Pharmacy was represented by 13 speakers and over 30 poster presenters at the 2018 American Association of Colleges of Pharmacy annual meeting in Boston.
Additionally, four student-faculty pairs were also honored with the AACP Walmart Scholars award — the most winners from the School in the award’s 14-year history, and more than any other school in 2018.
In the News
Oncologists shaves his head, plans to wear cancer-fighting gear during 5k | WTVD — Shawn Hingtgen, Ph.D.
Artificial intelligence helps scientists track particles | UPI.com — Sam Lai, Ph.D.
Antimalarial, antibiotics most falsified drugs in developing countries | The Guardian — Sachi Ozawa, Ph.D.
St. Baldrick’s Foundation gives grants to UNC, Duke for children’s cancer research | WRAL — Marina Sokolsky, Ph.D.
Artificial intelligence system designs drugs from scratch | Phys.org — Alex Tropsha, Ph.D., and Olexander Isayev, Ph.D.
How to Report Issues with the School Website
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Samit Ganguly, Ph.D., has joined DPET as a postdoctoral research associate working with Daniel Gonzalez, Pharm.D., Ph.D. Ganguly previously worked as an assistant research scientist at AstraZeneca in India in the field of drug metabolism and pharmacokinetics. He received his Ph.D. from University of Tennessee in 2018. His current research interests include pharmacokinetic and pharmacodynamic modeling of pediatric clinical data to characterize drug disposition and efficacy and optimize dosing in infants and children.
Abbey Kruse, M.Ed., has joined the School as the assistant director for experiential education. Kruse comes to UNC from the Coastal Carolina University Wall College of Business where she most recently served as the assistant director of academic advising. Kruse earned her undergraduate degree in educational studies from the University of Wisconsin-Milwaukee and her M.Ed. from Marquette University. In her new role in the Office of Curricular and Student Affairs, Kruse will be responsible for overseeing experiential learning initiatives and activities within the Pharm.D. program.
Casey Tak, M.P.H., Ph.D., has joined DPOP as an assistant professor at the School’s Asheville satellite campus. Tak earned his Ph.D. in pharmacotherapy outcomes research and health policy at the University of Utah, and his Masters of Public Health from Westminster College in Salt Lake City. Prior to joining the School, Tak served as a graduate assistant and a clinical research coordinator at the University of Utah. Tak’s research interests include biostatistics and epidemiological and economic data evaluations.
Joshua Thorpe, Ph.D., M.P.H., has been hired by DPOP as an associate professor with tenure. Thorpe earned his Ph.D. at the UNC Eshelman School of Pharmacy in 2005 and his M.P.H. in epidemiology at George Washington University in 2000. Thorpe comes to the School from the University of Pittsburgh, where he joined the faculty in 2011 and earned tenure in 2015. Previously, he worked at the University of Wisconsin. He will work closely with the Carolina Health Informatics Program while having continued affiliation with the Veterans Affairs Pittsburgh Health System. Thorpe’s research program focuses on assessing the roles of pharmaceutical policy, family caregivers and access to medications and services for older adults.
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Sept. 19 Employee Photo Session
Sept. 21–22 NCAP 2018 Annual Convention
Sept. 25 School Social
Sept. 25 Monthly K Drive Deletion
Sept. 26–29 GPEN 2018
Sept. 29 Scholarship Luncheon
Oct. 3 Employee Photo Session
Oct. 5 Candidates Day
Oct. 6 Family Day
- Kristy Ainslie, NIH National Institute of Allergy and Infectious Diseases (NIAID), Biomaterials to study tolerance immune induction kinetics, $385,768
- Kim Brouwer, Gilead Sciences, Inc., Evaluation of Drug Interactions with Human Organic Solute Transporter Alpha/Beta, $24,161
- Yanguang Cao, NIH National Institute of General Medical Sciences, Optimizing antibody-based therapy through a system platform of pharmacokinetics, pharmacodynamics and immunodynamics, $104,935
- Mackenzie Cottrell, Eastern Virginia Medical School, Pharmacokinetics Testing for CONRAD A15-137, titled Exploratory Pharmacokinetic and Pharmacodynamic Study of Oral F/TAF for the Prevention of HIV Acquisition, $921,036
- Paul Dayton, NIH National Cancer Institute, FELLOW:SAMANTHA FIX Image-guided, sonoporation-enhanced immunotherapy for pancreatic cancer treatment, $35,485
- David Drewry, NIH National Cancer Institute, Creation of in vivo active chemical probes for CAMKK2 to treat cancer, $649,225
- Stephen Eckel, Gilero, LLC (dba EG-GILERO), Vial Microbial Ingress for ArisureÂ® CVA with neural valve test protocol, $14,105
- Stephen Frye, NIH National Institute of General Medical Sciences, Discovery of Chemical Probes for Chromatin Readers, $90,000
- Nate Hathaway, NIH National Institute of General Medical Sciences, Mechanism Of Hp1-Mediated Heterochromatin Assembly And Durability In Live Cells, $30,000
- Shawn Hingtgen, NIH National Institute of Neurological Disorders and Stroke, Engineering stem cell therapies to understand and overcome glioblastoma adaption, $312,561
- Leaf Huang, NIH National Cancer Institute, Nano Approaches to Modulate Host Cell Response for Cancer Therapy, $2,167,454
- Lindsey James, NIH National Institute on Drug Abuse, Polycomb Repressive Complexes As Key Regulators Of Hiv Latency And Targets For Latency Reversal, $892,816
- Michael Jay, Dignify Therapeutics, SBIR: An optimized NK2R agonist for ‘on-demand’ voiding, $31,916
- Alexander Kabanov, NIH National Cancer Institute, Targeted Core Shell Nanogels for Triple Negative Breast Cancer, $562,533
- Alexander Kabanov, NIH National Cancer Institute, Targeted Magneto-Mechanic Nanotherapeutics for Cancer, $117,468
- Jennifer Lafata, NIH National Cancer Institute, e-Assist: A Post-Visit Patient Portal Tool to Promote Colorectal Cancer Screening, $571,799
- Andrew Lee, NIH National Institute of General Medical Sciences, The role of dynamics in enzyme mechanism and allostery, $320,330
- Craig Lee, American Heart Association, Fellow: R. Khatri Predicting Maternal Changes In Antihypertensive Drug Metabolism And Exposure During Pregnancy, $114,368
- Jian Liu, California Institute of Technology, Expedited Synthesis of Glycosaminoglycans Containing Defined Sulfation Domains, $80,976
- Adam Persky, American Association of Colleges of Pharmacy, Use of worked examples and problem solving to teach clinical note writing, $4,000
- Alexander Tropsha, NIH National Institute on Aging, Drug repurposing for Alzheimer’s disease using both observational and chemical genomics data, $794,078
- Tim Willson, Duke University, Cancer cell intrinsic and extrinsic actions of steroid hormones in breast tumors, $23,303
- Tim Wiltshire, North Carolina State University, Genetic Etiology of Cancer Drug Response, $270,670
- Tim Wiltshire, North Carolina State University, Systems Toxicogenomics of Endocrine Disrupting Chemicals in Brain, $103,399
- Thieker, D.F., Xu, Y., Chapla, D., Nora, C., Qiu, H., Felix, T., Wang, L., Moremen, K.W., Liu, J., Esko, J.D., Woods, R.J.Downstream Products are Potent Inhibitors of the Heparan Sulfate 2-O-Sulfotransferase (2018) Scientific Reports, 8 (1), art. no. 11832. https://www.scopus.com/inward/record.uri?eid=2-s2.0-85051198489&doi=10.1038%2fs41598-018-29602-4&partnerID=40&md5=c55b7e0234247c2891616d8539d0082d DOI: 10.1038/s41598-018-29602-4
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- Ho, J.-H., Stahl, E.L., Schmid, C.L., Scarry, S.M., Aubé, J., Bohn, L.M. G protein signaling-biased agonism at the k-opioid receptor is maintained in striatal neurons (2018) Science Signaling, 11 (542), art. no. eaar4309. https://www.scopus.com/inward/record.uri?eid=2-s2.0-85051321645&doi=10.1126%2fscisignal.aar4309&partnerID=40&md5=e47d5cb5bb1a36a83f8433bb36661ad6 DOI: 10.1126/scisignal.aar4309
- Rahim, A., Saito, Y., Miyake, K., Goto, M., Chen, C.-H., Alam, G., Morris-Natschke, S., Lee, K.-H., Nakagawa-Goto, K. Kleinhospitine e and Cycloartane Triterpenoids from Kleinhovia hospital (2018) Journal of Natural Products, 81 (7), pp. 1619-1627. https://www.scopus.com/inward/record.uri?eid=2-s2.0-85050740805&doi=10.1021%2facs.jnatprod.8b00211&partnerID=40&md5=3c6f39136faecb974df7708d2fb0f4a6 DOI: 10.1021/acs.jnatprod.8b00211
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- Pellock, S.J., Creekmore, B.C., Walton, W.G., Mehta, N., Biernat, K.A., Cesmat, A.P., Ariyarathna, Y., Dunn, Z.D., Li, B., Jin, J., James, L.I., Redinbo, M.R. Gut Microbial β-Glucuronidase Inhibition via Catalytic Cycle Interception (2018) ACS Central Science, 4 (7), pp. 868-879. https://www.scopus.com/inward/record.uri?eid=2-s2.0-85050512178&doi=10.1021%2facscentsci.8b00239&partnerID=40&md5=f332a3c89107ecaba8d8c62f943024d9 DOI: 10.1021/acscentsci.8b00239
- Senderowitz, H., Tropsha, A. Materials Informatics (2018) Journal of Chemical Information and Modeling, 58 (7), pp. 1313-1314. https://www.scopus.com/inward/record.uri?eid=2-s2.0-85050556711&doi=10.1021%2facs.jcim.8b00016&partnerID=40&md5=871f8e424e637e8a674920f6a783c172 DOI: 10.1021/acs.jcim.8b00016
- Vickerman, B.M., Anttila, M.M., Petersen, B.V., Allbritton, N.L., Lawrence, D.S. Design and Application of Sensors for Chemical Cytometry (2018) ACS Chemical Biology, 13 (7), pp. 1741-1751. https://www.scopus.com/inward/record.uri?eid=2-s2.0-85050390254&doi=10.1021%2facschembio.7b01009&partnerID=40&md5=2397e21c97594328cbafceebb5baea1e DOI: 10.1021/acschembio.7b01009
- Cooper, J.K., Li, K., Aubé, J., Coppage, D.A., Konopelski, J.P. Application of the DP4 Probability Method to Flexible Cyclic Peptides with Multiple Independent Stereocenters: The True Structure of Cyclocinamide A (2018) Organic Letters, 20 (14), pp. 4314-4317. https://www.scopus.com/inward/record.uri?eid=2-s2.0-85050195615&doi=10.1021%2facs.orglett.8b01756&partnerID=40&md5=b08cbf11e5974bff60016fa13d50332b DOI: 10.1021/acs.orglett.8b01756
- Strang, B.L., Asquith, C.R.M., Moshrif, H.F., Ho, C.M.-K., Zuercher, W.J., Al-Ali, H. Identification of lead anti-human cytomegalovirus compounds targeting map4k4 via machine learning analysis of kinase inhibitor screening data (2018) PLoS ONE, 13 (7), art. no. e0201321, . https://www.scopus.com/inward/record.uri?eid=2-s2.0-85050535307&doi=10.1371%2fjournal.pone.0201321&partnerID=40&md5=4e057efc53170c1f939cc73eb40ed6a8 DOI: 10.1371/journal.pone.0201321
- Agrafiotis, D.K., Holloway, M.K., Johnson, S.A., Reynolds, C.H., Stouch, T.R., Tropsha, A., Waller, C.L. Chemistry, information and Frank: a tribute to Frank Brown (2018) Journal of Computer-Aided Molecular Design, 32 (7), pp. 723-729. https://www.scopus.com/inward/record.uri?eid=2-s2.0-85050558464&doi=10.1007%2fs10822-018-0135-9&partnerID=40&md5=d82494cd1b98ee2c8645db4798bdf1a7 DOI: 10.1007/s10822-018-0135-9
- Fourches, D., Williams, A.J., Patlewicz, G., Shah, I., Grulke, C., Wambaugh, J., Richard, A., Tropsha, A. Computational Tools for ADMET Profiling (2018) Computational Toxicology: Risk Assessment for Chemicals, pp. 211-244. https://www.scopus.com/inward/record.uri?eid=2-s2.0-85050899559&doi=10.1002%2f9781119282594.ch8&partnerID=40&md5=5e8dd4b2d91bed16b4dfd78901d88e41 DOI: 10.1002/9781119282594.ch8
- Wang, M., McNitt, C.D., Wang, H., Ma, X., Scarry, S.M., Wu, Z., Popik, V.V., Li, Z. The efficiency of 18F labelling of a prostate specific membrane antigen ligand via strain-promoted azide-alkyne reaction: reaction speed versus hydrophilicity (2018) Chemical Communications, 54 (56), pp. 7810-7813. https://www.scopus.com/inward/record.uri?eid=2-s2.0-85049780009&doi=10.1039%2fc8cc03999b&partnerID=40&md5=d507f68cad243520ebe3df5ae59295c8 DOI: 10.1039/c8cc03999b
- Schaenzer, A.J., Wlodarchak, N., Drewry, D., Zuercher, W.J., Rose, W.E., Ferrer, C.A., Sauer, J.-D., Striker, R. GW779439X and its pyrazolopyridazine derivatives inhibit the serine/threonine kinase Stk1 and act as antibiotic adjuvants against β-lactam-resistant Staphylococcus aureus (2018) ACS Infectious Diseases, . Article in Press. https://www.scopus.com/inward/record.uri?eid=2-s2.0-85051110680&doi=10.1021%2facsinfecdis.8b00136&partnerID=40&md5=49050b7997dd69326ef57be5553d7a0d DOI: 10.1021/acsinfecdis.8b00136
- Brocca-Cofano, E., Xu, C., Wetzel, K.S., Cottrell, M.L., Policicchio, B.B., Raehtz, K.D., Ma, D., Dunsmore, T., Haret-Richter, G.S., Musaitif, K., Keele, B.F., Kashuba, A.D., Collman, R.G., Pandrea, I., Apetrei, C. Marginal effects of systemic CCR5 blockade with maraviroc on oral simian immunodeficiency virus transmission to infant macaques (2018) Journal of Virology, 92 (17), art. no. e00576-18. https://www.scopus.com/inward/record.uri?eid=2-s2.0-85051813088&doi=10.1128%2fJVI.00576-18&partnerID=40&md5=1e17372722f5aa3e97bb1fec93d77002 DOI: 10.1128/JVI.00576-18
- He, H., Liu, C., Wu, Y., Zhang, X., Fan, J., Cao, Y. A Multiscale Physiologically-Based Pharmacokinetic Model for Doxorubicin to Explore its Mechanisms of Cytotoxicity and Cardiotoxicity in Human Physiological Contexts (2018) Pharmaceutical Research, 35 (9), art. no. 174. https://www.scopus.com/inward/record.uri?eid=2-s2.0-85049784366&doi=10.1007%2fs11095-018-2456-8&partnerID=40&md5=51933f19409738d31bbfdd2c16eeadfb DOI: 10.1007/s11095-018-2456-8
- Oni-Orisan, A., Cresci, S., Jones, P.G., Theken, K.N., Spertus, J.A., Lee, C.R. Association between the EPHX2 p.Lys55Arg polymorphism and prognosis following an acute coronary syndrome (2018) Prostaglandins and Other Lipid Mediators, 138, pp. 15-22. https://www.scopus.com/inward/record.uri?eid=2-s2.0-85051388696&doi=10.1016%2fj.prostaglandins.2018.07.005&partnerID=40&md5=53517b37bad4b9d16c97fa7e3d170c07 DOI: 10.1016/j.prostaglandins.2018.07.005
- Innocenti, F., Owzar, K., Jiang, C., Etheridge, A.S., Gordân, R., Sibley, A.B., Mulkey, F., Niedzwiecki, D., Glubb, D., Neel, N., Talamonti, M.S., Bentrem, D.J., Seiser, E., Yeh, J.J., Van Loon, K., McLeod, H., Ratain, M.J., Kindler, H.L., Venook, A.P., Nakamura, Y., Kubo, M., Petersen, G.M., Bamlet, W.R., McWilliams, R.R. The Vitamin D receptor gene as a determinant of survival in pancreatic cancer patients: Genomic analysis and experimental validation (2018) PLoS ONE, 13 (8), art. no. e0202272, . https://www.scopus.com/inward/record.uri?eid=2-s2.0-85051556228&doi=10.1371%2fjournal.pone.0202284&partnerID=40&md5=d3bf448867a7fe028799b1aaf3aaf146 DOI: 10.1371/journal.pone.0202284
- Sanoff, H.K., Goldberg, R.M., Ivanova, A., O’Reilly, S., Kasbari, S.S., Kim, R.D., McDermott, R., Moore, D.T., Zamboni, W., Grogan, W., Cohn, A.L., Bekaii-Saab, T.S., Leonard, G., Ryan, T., Olowokure, O.O., Fernando, N.H., McCaffrey, J., El-Rayes, B.F., Horgan, A.M., Sherrill, G.B., Yacoub, G.H., O’Neil, B.H. Multicenter, randomized, double-blind phase 2 trial of FOLFIRI with regorafenib or placebo as second-line therapy for metastatic colorectal cancer (2018) Cancer, 124 (15), pp. 3118-3126. https://www.scopus.com/inward/record.uri?eid=2-s2.0-85050972636&doi=10.1002%2fcncr.31552&partnerID=40&md5=383fffa016493275ac2d874975f408a1 DOI: 10.1002/cncr.31552
- Schorzman, A.N., Lucas, A.T., Kagel, J.R., Zamboni, W.C. Methods and study designs for characterizing the pharmacokinetics and pharmacodynamics of carrier-mediated agents (2018) Methods in Molecular Biology, 1831, pp. 201-228. https://www.scopus.com/inward/record.uri?eid=2-s2.0-85051219288&doi=10.1007%2f978-1-4939-8661-3_15&partnerID=40&md5=f2b68f1222e611920ac83315b6744046 DOI: 10.1007/978-1-4939-8661-3_15
- Persky, A.M. A four year longitudinal study of student learning strategies (2018) Currents in Pharmacy Teaching and Learning, . Article in Press. https://www.scopus.com/inward/record.uri?eid=2-s2.0-85051531063&doi=10.1016%2fj.cptl.2018.08.012&partnerID=40&md5=a50dabefe7f646621dd78c7cd49f7030 DOI: 10.1016/j.cptl.2018.08.012
- Chu, Y., Palmer, S., Persky, A.M. Assessing metacognition in the classroom: Student help-seeking behavior (2018) Currents in Pharmacy Teaching and Learning, . Article in Press. https://www.scopus.com/inward/record.uri?eid=2-s2.0-85051468303&doi=10.1016%2fj.cptl.2018.08.011&partnerID=40&md5=5f84bc2d79c54e929214ff4bb2c39539 DOI: 10.1016/j.cptl.2018.08.011
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- Diep, J.K., Covelli, J., Sharma, R., Ruszaj, D.M., Kaye, K.S., Li, J., Straubinger, R.M., Rao, G.G. Comparison of the composition and in vitro activity of polymyxin B products (2018) International Journal of Antimicrobial Agents, . Article in Press. https://www.scopus.com/inward/record.uri?eid=2-s2.0-85051037029&doi=10.1016%2fj.ijantimicag.2018.05.014&partnerID=40&md5=c8c9cb1ec765e17214e53ac75095c36f DOI: 10.1016/j.ijantimicag.2018.05.014
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