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1131 Bioinformatics

April 2018

Seminar: “A Molecular Arms Race: HIV versus the immune system”

April 10, 2018 @ 9:30 am - 10:30 am

Pamela Björkman, Ph.D., California Institute of Technology

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Seminar: “Theory and Simulation of Biomolecular Systems: Overcoming the Multiscale Challenge”

April 10, 2018 @ 11:00 am - 12:00 pm

Gregory Voth, PhD, University of Chicago

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Seminar: “Characterizing the Bioactivities of Thiopeptides: Potential Host-Directed Therapeutics”

April 12, 2018 @ 10:00 am - 11:00 am

Anti-Infective Group- Kelly Bird from the Bowers Lab

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Seminar: “Building a spindle and segregating chromosomes without centrosomes: Oocyte meiosis in C. elegans”

April 13, 2018 @ 12:00 pm - 1:00 pm

Sadie Wignall, PhD, Assistant Professor of Molecular Biosciences, North Western University

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Pharmaceutical Sciences Open House

April 13, 2018 @ 1:00 pm - 6:00 pm

A career in pharmaceutical sciences is sometimes overlooked by students interested in applied biological science, and it is our goal to shed some light on this career path and the opportunities available at the Eshelman School of Pharmacy and beyond. The 2nd Annual Open House will be from 1:00-6:00pm in the Bioinformatics Building Room 1131 on UNC’s Campus on April 13. This year, the program will consist of an opening by Dr. Morris Clarke (a former faculty member at Winston…

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Seminar: “Interferon-stimulated genes in antiviral immunity”

April 17, 2018 @ 9:30 am - 10:30 am

John Schoggins, PhD, University of Texas Southwestern Medical Center

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Seminar: “Proteomics and Precision Medicine”

April 17, 2018 @ 11:00 am - 12:00 pm

Jun Qin, PhD, Baylor, College of Medicine

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Seminar: “Neural and Non-Neural Network in Hippocampal Plasticity”

April 17, 2018 @ 4:00 pm - 5:00 pm

Shaoyu Ge, PhD, Associate Professor, Neurobiology and Behavior, SUNY Stony Brook

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Seminar: “Efficiently surveying the chromatin occupancy landscape”

April 27, 2018 @ 12:00 pm - 1:00 pm

Alexander J Hartemink, Professor Biology and Computer Science, Duke University

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May 2018

Seminar: “Metabolic control and signaling circuits in lymphocyte fate decisions”

May 1, 2018 @ 9:30 am - 10:30 am

Hongbo Chi, PhD, St. Jude Children’s Research Hospital

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Seminar: “Top Down Proteomics for Precise Description of KRAS Gene Products in Colorectal Cancer”

May 1, 2018 @ 11:00 am - 12:00 pm

Neil Kelleher, PhD, Northwestern University

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Seminar: “RNA Virus Infection and Evolution”

May 8, 2018 @ 9:30 am - 10:30 am

Raul Andio, PhD, University of California, San Francisco

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Steelman Symposium to Honor Gary L. Johnson

May 15, 2018 @ 1:00 pm - 6:20 pm

Invited speakers: Roger J. Davis, PhD, FRS  - Investigator, HHMI, Arthur Smith Chair & Professor, Program in Molecular Medicine, U. of Massachusetts Medical School Talk title: "Stress Signaling in the Mammary Epithelium James S. Duncan, PhD  - Cancer Biology, Fox Chase Cancer Center Talk title: "Defining K-Ras mutation specific kinome signature and vulnerabilities in colorectal cancer" Amy Abell, PhD - Biological Sciences, U. Memphis Talk title: "Epigenetic regulation of epithelial-mesenchymal transition in stem cells and Claudin-low breast cancer" Michael P. Czech,…

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Seminar: “Inhaled Drugs to Treat Tuberculosis”

May 17, 2018 @ 10:00 am - 11:00 am

Miriam Braunstein - Anti-Infectives Group

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Seminar: “Cytoskeletal self-organization and cell morphogenesis”

May 23, 2018 @ 11:00 am - 12:00 pm

Alexander Breshadsky, PhD, Mechanobiology Institute, National University of Singapore

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June 2018

Seminar: “Mechanobiology of cell protrusions”

June 22, 2018 @ 1:00 pm - June 26, 2018 @ 2:00 pm

Amrinder Nain, PhD, Associate Professor, Mechanical Engineering, Virginia Tech

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Seminar: “CD8+ T cell residency and recirculation in HIV-infected lymph nodes”

June 28, 2018 @ 9:00 am - 10:00 am

Michael Betts, Department of Microbiology, University of Pennsylvania

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August 2018

Seminar: “Spatial Organization of UPEC biofilms as a function of oxygen gradients”

August 28, 2018 @ 9:30 am - 10:30 am

Maria Hadjifrangiskou, PhD, Vanderbilt University

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Seminar: “BCMP Seminar: Targeting Cell Signaling Pathways for Cancer”

August 28, 2018 @ 11:00 am - 12:00 pm

Wenyi Wei, PhD, Professor, Department of Pathology, Beth Israel Deaconess Medical Center/Harvard Medical School

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September 2018

NSF GRFP Fellowship Workshop-Enhancing your Competitiveness

September 18, 2018 @ 2:00 pm - 3:30 pm

The prestigious NSF Graduate Research Fellowship is open to undergraduate seniors and first & second year graduate students in STEM fields who do not have a Masters degree or more than 12 months of postbaccalaureate training. The fellowship offers 3 years of support, $34,000 annual stipend, $12,000 cost-of-education allowance (to the institution), international research and professional development opportunities, and XSEDE Supercomputer access.   Register: http://tinyurl.com/y8b4aqc4

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Seminar: “How does HIV persist and how can we eliminate it?”

September 20, 2018 @ 9:00 am - 10:00 am

John W. Mellors, MD< Professor of Medicine, Chief, Division Infectious Diseases and Endowed Chair for Global Elimination of HIV and AIDS, University of Pittsburgh

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Seminar: “Cullin-RING Ubiquitin Ligases: A Microcosm of Discovery in Biology”

September 21, 2018 @ 4:00 pm - 5:00 pm

Dr. Ray Deshaies, Senior Vice President of Research at Amgen, Inc.

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Seminar: “Immune control of Zika virus infection”

September 25, 2018 @ 9:30 am - 10:30 am

Mehul Suthar, PhD, Emory Vaccine Center

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October 2018

Seminar: “Distinct Thresholds of Apoptosis: The Cautious and the Willing”

October 2, 2018 @ 4:00 pm - 5:00 pm

Mohanish Deshmukh, UNC

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Seminar: Cis- and Trans-Regulatory Logics of Blood Stem Cells and Cancer

October 9, 2018 @ 11:00 am - 12:00 pm

Jian Xu, PhD, UT Southwestern University

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Seminar: David Toczyski, UCSD

October 9, 2018 @ 4:00 pm - 5:00 pm
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Seminar: “Breast SPORE: The Development of CDK 4/6 Inhibitors in Breast Cancer”

October 11, 2018 @ 12:00 pm - 1:00 pm

Richard Finn, MD, Professor of Clinical Medicine, Jonsson Comprehensive Cancer Center, Geffen School of Medicine at UCLA

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Seminar: “Recurring conflicts with a single predatory phage drive the evolution of Vibrio cholera”

October 16, 2018 @ 9:30 am - 10:30 pm
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Seminar: “Discovery of Selective Inhibitors for Histone Methyltransferases” – Jian Jin PhD, Ichan SOM, Mt. Sinai

October 16, 2018 @ 4:00 pm - 5:00 pm
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Seminar: “Natural Killer Cell Recognition and Responses”

October 23, 2018 @ 9:30 am - 10:30 am

Lewis L. Lanier, PhD, University of California, San Francisco

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Seminar: “Cooperative Oncogenic Signaling of 3q26 Genes in Lung Cancer”

October 23, 2018 @ 11:00 am - 12:00 pm

Verline Justilien, PhD, May Clinic of Medicine and Science

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Seminar: “G-proteins to Kinases to Epigenetics: Trying to Understand Cell Signaling and Human Disease”

October 23, 2018 @ 4:00 pm - 5:00 pm

Gary L. Johnson, PhD, UNC-CH

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Seminar: David Dunson, PhD, Arts and Sciences Professor of Statistical Science, Duke University

October 26, 2018 @ 12:00 pm - 1:00 pm
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Seminar: “Alchemical free energy approaches in ligand refinement and protein engineering”

October 30, 2018 @ 11:00 am - 12:00 pm

Irina Ethell, PhD, UC Riverside

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Seminar: “Understanding and Targeting Glioblastoma Treatment pHailures”

October 30, 2018 @ 4:00 pm - 5:00 pm

Anita B. Hjelmeland, UAB

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November 2018

Seminar: “Innate Immune Defense and Repair Functions at the Skin Barrier”

November 6, 2018 @ 9:30 am - 10:30 am

Amanda MacLeod, MD, Duke University School of Medicine

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Seminar: “The Stem Cell Biology Group aims to understand the regulation of the pluripotent state in cells in culture and during early embryonic development New Insights and Strategies for Cancer Therapy”

November 6, 2018 @ 11:00 am - 12:00 pm

Guang Hu, PhD, NIEHS, Stepm Cell Biology Group

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Seminar: Jude Samulski, UNC-CH

November 6, 2018 @ 4:00 pm - 5:00 pm
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Seminar: “Cellular and Molecular models for epigenetic studies of human diseases”

November 9, 2018 @ 12:00 pm - 1:00 pm

John  H. Greally, PhD, MB, B Ch, Albert Einstein College of Medicine

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Seminar: “Managing metals in microbes: new insights from Bacillus subtilis”

November 13, 2018 @ 9:30 am - 10:30 am

John Helmann, PhD, Cornell University

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Seminar: “The OncoPPi Network: Cancer-associated protein-protein interactions for therapeutic target discovery”

November 13, 2018 @ 4:00 pm - 5:00 pm

Haian Fu, PhD, Emory

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Seminar: “Cellular and Molecular models for epigenetic studies of human diseases”

November 16, 2018 @ 12:00 pm - 1:00 pm

John  H. Greally, PhD, MB, B Ch, Albert Einstein College of Medicine

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January 2019

IMPACT Internship Panel/Info Session & Q&A

January 9, 2019 @ 2:30 pm - 3:30 pm

ImPACT Internships: Thinking about an internship in your future? Come hear from ImPACT Interns about their experiences at a variety of types of jobs during their ImPACT Internships! Plus learn more about the application and placement process, get tips on creating a successful application at the Info Session and Q&A with Dr. Patrick Brandt. ImPACT Applications for the 2019 Cycle due Feb 1. Register for the ImPACT Internship Panel/Info Session here: http://tinyurl.com/yaptodgc

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Seminar: “AI for Healthcare: Recent Advances”

January 10, 2019 @ 2:00 pm - 3:00 pm

Regina Barzilay, PhD, Delta Electronics Professor, EECS MacArthur Fellow, MIT Computer Science and Artificial Intelligence Lab

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Seminar: “Modulation of innate immune signaling and epithelial cell function by the obligate pathogen Chlamydia trachomatis”

January 11, 2019 @ 12:00 pm - 1:00 pm

Raphael H Valdivia, PhD, Professor of Molecular Genetics and Microbiology, Vice Dean for Basic Science, Duke University

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CICBDD Seminar – Speaker Dr. Nathanael S. Gray, Harvard Medical School/Dana Farber Cancer Institute

January 14, 2019 @ 4:00 pm - 5:30 pm

January 14 4pm 1131 Bioinformatics The development of new anti-cancer therapies continues to be massively outpaced by the rapidly expanding knowledge into the biological mechanisms that underpin the development of cancer.  One major obstacle is that many potentially interesting targets are challenging to drug.  This lecture will focus on strategies using covalent inhibitors and small molecule degraders which hold the promise of making many previously challenging targets druggable.  In particular, we will focus on the use of these approaches to…

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Seminar: “Career Conversion”

January 18, 2019 @ 12:00 pm - 1:00 pm

Don Alexander, CPC, CFP, President and Managing Director, GeneCoda Executive and Professional Search

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Seminar: “Role of Matrix Metalloproteinase 9, Perineuronal Nets and Cortical Circuits in Auditory Hyperexcitability in Fragile X Syndrome Mouse Model”

January 29, 2019 @ 11:00 am - 12:00 pm

Iryna Ethell, PhD, Professor of Biomedical Sciences

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Seminar: “Cullin-RING ubiquitin ligases: a microcosm of discovery in biology”

January 29, 2019 @ 4:00 pm - 5:00 pm

Raymond Deshaies, PhD, Senior Vice President, Division of Research, Amgen, Inc.

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Seminar: “Basal transcription factor TFIID: epigenetics, stem cells and assembly”

January 31, 2019 @ 11:00 am - 12:00 pm

Marc Timmers, PhD, Professor of Medical Epigenetics, University of Frieburg Germany

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February 2019

Seminar: “Tracing 3D DNA structures during embryogenesis”

February 1, 2019 @ 12:00 pm - 1:00 pm

Allistair Boettiger, Assistant Professor of Developmental Biology at Stanford University

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Seminar: Nils Gehlenborg, PhD, Assistant Professor of Developmental Biology, Stanford University

February 8, 2019 @ 12:00 pm - 1:00 pm
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Seminar: “Conditional control of protein function through protein engineering and genetic code expansion”

February 18, 2019 @ 11:00 am - 12:00 pm

Duy Nguyen, PhD, Post-doctoral Research, University of California, San Francisco, Department of Pharmaceutical Chemistry

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“Protein-Protein Interactions-From Inhibition to Degradation”

February 25, 2019 @ 11:00 am - 12:00 pm

George Burslem, PhD, Molecular, Cellular and Developmental Biology, Yale University

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“Protein Complexes that Modify Chromatin for Transcription”

February 26, 2019 @ 11:00 am - 12:00 pm

Jerry Workman, PhD, Investigator, Stowers institute for Medical Research

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March 2019

“Duplicating the genome and re-establishing the chromatin landscape”

March 1, 2019 @ 12:00 pm - 1:00 pm

David MacAlpine, Associate Professor, Pharmacology and Cancer Biology, Duke University

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“Targeting BAF (SWI/SNF) and PBAF dysfunction in cancer”

March 8, 2019 @ 12:00 pm - 1:00 pm

H. Courtney Hodges, Assistant Professor, Department of Molecular and Cellular Biology, Dan L Duncan Comprehensive Cancer Center, Balor College of Medicine, MD Anderson Center for Cancer Epigenetics

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“Opioid-induced Plasticity and the Intersection with Pain”

March 12, 2019 @ 4:00 pm - 5:00 pm

Dr. Jose Moron-Concepcion, WUSTL

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“The role of DNA looping and break formation in HPV replication”

March 19, 2019 @ 9:30 am - 10:30 am

Lou Laimins, PhD, Northwestern University Feinberg School of Medicine

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“CONFOUNDING ROLES OF ESSENTIAL CARETAKER GENES IN TUMORIGENESIS: INSIGHTS GAINED FROM BCCIP STUDIES”

March 19, 2019 @ 11:00 am - 12:00 pm

Zhijuan Shen PhD, Rutgers Cancer Institute of New Jersey, Radiation Oncology

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“Ubiquitin Signaling and Cell Cycle Control”

March 19, 2019 @ 4:00 pm - 5:00 pm

Dr. Michael Emanuele of UNC, Dept of Pharmacology

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“Natural killer cells and missing-self”

March 26, 2019 @ 9:30 am - 10:30 am

Wayne Yokoyama, MD, Washington University

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“Local and Targeted Redox Therapies for the Vasculature”

March 26, 2019 @ 4:00 pm - 5:00 pm

Dr. Edward Bahnson, UNC, Dept. of Cell Biology and Physiology

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“Calm under stress: gene regulatory networks in archaeal extremophiles”

March 29, 2019 @ 12:00 pm - 1:00 pm

Amy Schmid, PhD, Associate Professor of Biology, Duke Center for Genomic and Computational Biology, Duke University

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April 2019

“Quantitation of Single Molecule Combinations of Post-Translational Modifications Reveals New Mechanistic Landscapes of Chromatin Regulation”

April 9, 2019 @ 11:00 am - 12:00 pm

Nicolas Young, PhD, Assistant Professor, Baylor College of Medicine

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“Deciphering the Regulatory Ubiquitin Code on the Ribosome”

April 9, 2019 @ 4:00 pm - 5:00 pm

Dr. Eric Bennett, UCSD

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“Quantitative Models of Cell-Cell Signaling in Development”

April 12, 2019 @ 12:00 pm - 1:00 pm

The GMB Friday Seminar Series welcomes Gregory T Reeves

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Oliver Smithies Investigators Honorary Lecture

April 15, 2019 @ 3:00 pm - 4:00 pm
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“Nucleic acid detection in host defense and autoimmunity”

April 23, 2019 @ 9:30 am - 10:30 am

Daniel Stetson, PhD, University of Washington

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“A Novel Targeted Nonotherapeutic Approach to Stop Hemorrahage”

April 23, 2019 @ 11:00 am - 12:00 pm

Melina Kibbe, Md, Distinguished Professor and Chair, Division of Surgery, UNC SOM

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“The Role of Allosteric Communication in Functional Selectivity and Promiscuity of GPCRs”

April 23, 2019 @ 4:00 pm - 5:00 pm

Dr. Vaidehi Nagarajun, City of Hope

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“Transposable elements and epigenome evolution”

April 26, 2019 @ 12:00 pm - 1:00 pm

Ting Wang, Distinguished Professor of Medicine, Department of Genetics, Washington University School of Medicine

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Seminar: Wes Trotter, PhD, Director, Medicinal Chemistry, Merck Laboratories

April 26, 2019 @ 12:20 pm - 1:30 pm

Topic: TBA

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May 2019

“Many weak trans eQTLs drive omnigenic architecture of human complex traits”

May 3, 2019 @ 12:00 pm - 1:00 pm

The Genetics and Molecular Biology Friday Seminar Series and the Curriculum in Bioinformatics and Computational Biology welcomes Jonathan Pritchard of Stanford University

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“Signaling at the T Cell Antigen Receptor”

May 7, 2019 @ 4:00 pm - 5:00 pm

Dr. Larry Samuelson, NIH/NCI

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“UNC Computational Medicine Seminar: AI for Healthcare: Recent Advances”

May 9, 2019 @ 2:00 pm - 3:00 pm

Regina Barzilay, PhD, Delta Electronics Professor, EECS MacArthur Fellow MIT Computer Science and Artificial Intelligence Lab

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“K63 Ubiquitin and Translation Control in Response to Oxidative Stress”

May 14, 2019 @ 4:00 pm - 5:00 pm

Gustavo Silva, PhD, Assistant Professor, Department of Biology, Duke University

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June 2019

“Children’s Research Institute Seminar Series: Acute Leukemia Genomics Across the Translational Spectrum”

June 11, 2019 @ 12:15 pm - 1:15 pm

Thomas Alexander, MD, MPH, Assistant Professor, Department of Pediatrics, Division of Hematology/Oncology, UNC School of Medicine, UNC Lineberger Comprehensive Cancer Center

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July 2019

“Investigating the genetic makeup of clear cell renal cell carcinoma”

July 2, 2019 @ 2:00 pm - 3:30 pm

Genetics & Molecular Biology Student Defense Aleisha Smith Student of William Kim

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Responsible Conduct of Research

July 17, 2019 @ 8:00 am - July 19, 2019 @ 12:00 pm

This 3-day course covers all NIH-required topics for the first phase of responsible conduct of research training. Individuals who have had prior RCR training may volunteer to serve as discussion leaders for the course to document ongoing RCR exposure if needed for training grants.

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August 2019

Seminar: David Fruman, PhD – University of California, Irvine

August 27, 2019 @ 11:00 am - 12:00 pm
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September 2019

Seminar: “Cryo-EM of Helical Polymers at Near-Atomic REsolution Yields Many Surprises”

September 10, 2019 @ 11:00 am - 12:00 pm

Edward Egelman, PhD - University of Virginia

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Seminar: “Regulation of Cellular Quiescence”

September 17, 2019 @ 11:00 am - 12:00 pm

Larisa Litovchick, PhD - Virginia Commonwealth University

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Seminar: “Advancing the science of clinical variant interpretation using validated functional assays”

September 24, 2019 @ 11:00 am - 12:00 pm

Jonathan Berg, MD, PhD - UNC

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October 2019

Seminar: “Alternative splicing and membrane trafficking in development and disease”

October 1, 2019 @ 11:00 am - 12:00 pm

Jimene Giudice, PhD - UNC

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Seminar: “The highs and lows of cryo-EM and its use in studying molecular machines of mass destruction”

October 8, 2019 @ 11:00 am - 12:00 pm

Gabe Lander, PhD - Scripps Research Institute

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Seminar: “Regulation of Exocytosis by inhibitory GPCRs and Gbg subunits”

October 15, 2019 @ 11:00 am - 12:00 pm

Heidi Hamm, PhD - Vanderbilt University

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Seminar: “Catching a Glimpse of Lipoprotein Lipase”

October 22, 2019 @ 11:00 am - 12:00 pm

Kathryn Gunn, PhD - UNC

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Seminar: “Proteogenomics: A New Avenue for Cancer Research”

October 29, 2019 @ 11:00 am - 12:00 pm

Bing Zhang, PhD - Baylor College of Medicine

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November 2019

Friday – GMB Seminar Series: Karla Neugebauer

November 1, 2019 @ 12:00 pm - 1:00 pm

The GMB Friday Seminar Series welcomes Karla Neugebauer, Department of Molecular Biophysics & Biochemistry (Acting Chair), Department of Cell Biology, Director of the Yale Center for RNA Science and Medicine at Yale University on Friday, November 1, 2019. Dr. Neugebauer’s talk title is “Eukaryotic RNA Synthesis and Processing in the Nuclear Landscape”.

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Seminar: “Selective recognition of lanthanides in biology”

November 5, 2019 @ 11:00 am - 12:00 pm

Joseph Cotruvo, PhD - Penn State University

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“Arsenic and the human genome: susceptibility and response to exposure”

November 8, 2019 @ 12:00 pm - 1:00 pm

Brandon Pierce, Assistant Professor, Departments of Health Studies and Genetics at the University of Chicago

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Seminar: “Functional overlap and specialization of divergent actins in Chlamydomonas”

November 15, 2019 @ 12:00 pm - 1:00 pm

Prachee Avasthi, Assistant Professor, Department of Anatomy and Cell Biology at University of Kansas Medical Center

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Seminar: “Detecting RNA methylation and its role in gene expression”

November 19, 2019 @ 11:00 am - 12:00 pm

Kate Meyer, PhD - Duke University School of Medicine

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Seminar: “Cellular and molecular models for epigenetic studies of human disease”

November 22, 2019 @ 12:00 pm - 1:00 pm

John Greally, Professor of Genetics, Medicine, and Pediatrics at Albert Einstein College of Medicine

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December 2019

Seminar: “RNA Binding and Regulation in Normal and Disease States”

December 3, 2019 @ 11:00 am - 12:00 pm

Daniel Dominguez, PhD - UNC

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March 2022

Determining the regulatory logic of cancer cells at single-cell resolution

March 30, 2022 @ 12:00 pm - 1:00 pm

Via Zoom: https://zoom.us/j/96318452720?pwd=MGMyOUVRSitYQ29mSXB5ZURvd0VPUT09#success Hector L. Franco Assistant Professor UNC Department of Genetics

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April 2022

Learning mechanistic models of cell differentiation from single-cell multi-omic data

April 1, 2022 @ 12:00 pm - 1:00 pm

Via Zoom Meeting https://zoom.us/j/92049794378?pwd=M1hWS1dtNTRKWTdPd3BiejJ3TlFxdz09#success GMB Friday Seminar Series Joshua D. Welch Assistant Professor University of Michigan Hosted by Yuchao Jiang

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Immune responses to hepatitis A virus (HAV) in a mouse model

April 6, 2022 @ 12:00 pm - 1:00 pm

Via Zoom Meeting https://zoom.us/j/96318452720?pwd=MGMyOUVRSitYQ29mSXB5ZURvd0VPUT09#success Genetics Research Colloquium Ichiro Misumi Assistant Professor UNC Department of Genetics

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GMB Student Defense – Gene Regulation in Time and Space

April 8, 2022 @ 2:00 pm - 3:00 pm

Via Zoom Meeting https://zoom.us/j/91474555209?pwd=citqZ1ViaTV6MVRQM1RCQlBnbDF2UT09#success Katie Metz Reed Doug Phanstiel Lab

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